Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Medicinal signaling cells have been recently applied in the field to promote superior healing of the wounds. Not only medicinal signaling cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. Lipogems have shown beneficial therapeutic effect of adipose-derived medicinal signaling cells in burn wound healing and current results are very promising.