Herein, we present the state of the art and Lipogems® technology. The Lipogems® technology, is an easy-to-use system designed to harvest, process, and inject purified fat tissue and is characterized by optimal handling ability and a great regenerative potential based on adipose-derived MSCs. The adipose tissue is washed, emulsified, and rinsed and adipose cluster dimensions gradually are reduced to about 0.3 to 0.8 mm. In the resulting product, pericytes are retained within an intact stromal vascular niche and are ready to interact with the recipient tissue after transplantation, thereby becoming MSCs and starting the regenerative process.